Research progress on aging-related secretory phenotype and development of anti-aging drugs
DOI:
https://doi.org/10.64135/d6vw0d55Keywords:
secretory phenotype related to aging, Aging cell eliminator, Aging morphology regulating agent, Anti-aging drugs, SecretomeAbstract
Abstract:Aging-related secretory phenotype (SASP) is a complex combination of factors secreted by aging cells, including cytokines, chemokines, growth factors and proteases, which play a key role in aging and the development of corresponding diseases. In recent years, studies have shown that SASP participates in intercellular communication through autocrine and paracrine mechanisms, which not only causes inflammation and fibrosis of local tissues, but also drives systemic aging as a whole. In this review, the molecular composition, regulatory mechanism and biological function of SASP are systematically summarized, and the development methods of anti-aging drugs targeting SASP are emphatically discussed, including removing aging cells, inhibiting the release of SASP and intervening aging-related signal pathways. The challenges and future development trends in this field are also prospected, which provides theoretical evidence for developing new anti-aging intervention approaches.
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