Research Progress on the Role of PKM2 in the Cell Cycle of Tumor Cells and Immune Cells

Abstract

This article comprehensively discusses the important role of pyruvate kinase M2 (PKM2) in cell cycle regulation, immune cell function, and cancer treatment. As a multifunctional protein, PKM2 plays a key role in cell metabolism, signal transduction, and transcriptional regulation, affecting biological processes such as cell proliferation, differentiation, and polarization. We conduct an in-depth analysis of the mechanisms by which PKM2 influences cell cycle checkpoints, Th17 cell differentiation, and macrophage polarization, and explore its potential value in cancer therapy. Finally, we look forward to future research directions to more fully reveal the biological functions and clinical application prospects of PKM2.